
DNA-based data storage is a cutting-edge technology that offers exceptional information density and longevity. However, the processes of writing, storing, and reading data in DNA formats are prone to noise and errors at various stages. Achieving reliable storage at a reasonable cost necessitates advanced error-correction methods. Traditional error-correction, which primarily addresses substitution and erasure errors, falls short due to the unique characteristics of the DNA storage medium. This has led to the emergence of new coding challenges and the need for enhancements to existing techniques. These challenges include developing codes and fundamental bounds for handling insertions, deletions, and substitutions, reconstructing sequences, addressing duplication errors, designing constrained codes, and much more. Moreover, ensuring data privacy—a critical requirement for any storage technology—has not been significantly explored in the context of DNA-based data storage.
This Special Issue encourages the research community working on topics related to DNA-based data storage to advance the mathematical foundations of error-correction in DNA storage systems.